A Patient with Intravenous Immunoglobulin-Responsive Lower Motor Neuron Syndrome
نویسندگان
چکیده
We report a 50-year-old woman who developed localized proximal muscle weakness, in addition to transient elevation of antibodies to GM1 ganglioside, without multifocal conduction block. She was treated with intravenous immunoglobulin (IVIg) and steroid pulse therapy, which were effective for over 10 years. Her clinical course and laboratory tests were consistent with lower motor neuron syndrome (LMNS) with localized proximal muscle weakness. We suggest that some patients diagnosed as LMNS may remain responsive to IVIg or steroid pulse therapy for a long time.
منابع مشابه
Intravenous immunoglobulin treatment in lower motor neuron disease associated with highly raised anti-GM1 antibodies.
The effect of intravenous immunoglobulin (IVIg) treatment was studied in five patients with lower motor neuron disease associated with highly raised anti-GM1 antibodies but without evidence of conduction block on neurophysiological examination. The patients received IVIg treatment (0.4 g/kg for five consecutive days) in an open study. Only one patient responded to IVIg treatment, which was conf...
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BACKGROUND Multifocal motor neuropathy with conduction block (MMN) is a treatable disorder that can be mistaken for other lower motor neurone syndromes. Existing electrophysiological diagnostic criteria for MMN are restrictive. In particular, many are cautious about diagnosing conduction block (CB) in the presence of abnormal temporal dispersion (TD). OBJECTIVE To study the significance of TD...
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